If you play your stack "correctly" it makes no difference at all - but it is alot harder to play half stacked correctly than it is to play deep or short because your options are limited. Granted, the players playing against you have the same effective stack size, so if you are used to playing that stack size you may very well have an advantage. But, it is just a stupid stack size because you are too deep to be shoving to pick up dead money or other short stack strats, and you can't play implied odds
hands as if you were deep. You are therefore limiting your hand range/strategy to one that effectively works with such a stack size, which is obviously much smaller.
So it is more a function of greatly limiting the options available to you. But if you could make it work then more power to you. But i'd buy in for full and try to learn how to play "proper poker".