I think most of the time i will fold unsuited connectors even in position because i don't want to bleed away chips. But if i am in the big blind and get very good odds
then thats when i call with them and see a flop.
I think the drawback of playing low connectors is that if you flop a pair, you might call to see another card, If you flop a gutshot you still probably call, if you flop open enders den you definitely call/bet flop. In all these scenarios you are paying more chips. But the drawback most of the times is even if you improve your hand you still have a good chance of having the second best hand.
For instance you flop a pair and turn/river two pair. Still opponent might might have improved to higher two pair.(Hence we lose more chips)
Other scenario is flopping draws and chasing them and bleeding more chips.
Another scenario is hitting a straight but having the bottom end of it. For eg, you call with 67. Flop has 8 9 x. You chase and might hit a straight but you might well lose because two higher straights beat you - 7 10 and 10 Jack. But we barely fold straights so we lose again. (most of our chips here)
And then of course there are some other rare but possible instance where if we hat two pair but lose to a set. (45 vs 44, 78 vs 77 etc).
Last but not least is Getting Counterfeited - Call with such cards and the opponent cannot fold over pair or simply top pair top kicker. And our two pair becomes a too trash.
If you want to enjoy having the opportunity to face such nerve wracking, mind blowing, tilt inducing scenarios then go ahead - have some adrenaline rush.