There are quite a few meaningful differences, probably too many to try to list, never mind discuss. That said, here are a couple.
It's easier to play tight since the blinds don't rise. Note that this doesn't mean you should be a nit, just that you won't have the same urgency to create action. For example, you should never be short-stacked, so you should never be in open-shove or fold situations. This also means your post-flop play tends to take on greater importance.
It can also be easier to play loose. You're never risking a large portion of your stack to open-raise, or to call a normal opening. It also won't severely damage your stack to 3bet fold, so you can do that more too.
You can table- and even seat select to your advantage.
Since you can be at a table with some of the same people for hours, your reading and ranging abilities can be more important.