Against preflop raises, I'd be very careful playing a hand like A6s. Player types are no irrelevant with speculative hands like this - they're EVERYTHING.
I would play these against loose players more often than I play them against TAG. If TAG is raising preflop, you're probably going to figure them for A/high kicker at least, which pretty much leaves you with a hand that needs to flop two pair or better to win. Even if you do flop your flush or flush draw, it is unlikely you'll get paid off by a TAG player unless he or she has a strong hand like three of a kind or better.
Against loose players, you can probably win the pot by hitting a pair of Aces, and if you do flop that flush or flush draw, you can build a large pot for yourself.
Also, a good strategy to use at least some of the time may be to raise in early position preflop. For two reasons: 1. You eliminate weaker hands that would need to call a raise cold and 2. If you get re-raised, you know right off the bat your speculative hand may be crushed and you can save yourself some money when an Ace hits the flop. Just calling doesn't really give you any information.
In MP, you may want to raise if you are the first one in the pot for the same reasons stated above. If you aren't the first one in, it's probably a good idea to just fold. In MP, calling can thrust you into a tricky situation, so I like to either raise or fold.
In late position, you could raise or call. I like to call with a hand like AXs in late position. Your ultimate goal for it is to hit a big hand, so the more people contributing to the pot, the better. You can also get a better feel for the pot odds
if you do flop a big draw because everyone else is acting first.