The biggest thing with Zoom poker is that you are almost always at an information disadvantage because you get to see the same opponents much less often than at a standard 9 or 6 max table.
So you have to play a more ABC brand of poker where essentially you just "play by the book" to use a tired cliche. What I mean more specifically is your reads will be weak and you can't really take the custom lines that you can like in a traditional ring game.
Another big difference is that you can't get position on the fish and tilt them or even the regs for that matter. So this means that there is no real history or a dynamic between you and anyone. Again, this leads back to playing an ABC version of poker where you just make the "standard plays".
One of the good things from a strategy perspective with Zoom though is that you can get away with much more aggression at all stages of the hand because while we don't know much about our opponents, they don't know much about us either.
This means that when you take an aggressive line like 3Betting or 4Betting light preflop they will be more likely to lay it down instead of fight back. They will give you the benefit of the doubt more often.
I actually just came out with a new video series today with 6 hours of live play both at the regular tables and at Zoom. I discuss the differences between Zoom and the regular tables in depth.