I would open raise all of them, and fold to 3B.
Cbet against a nit with a high fold to Cbet, and bet big if you hit your set against a fish. If you're calling raises OOP, make sure you have good implied odds
, generally at least 15-1. Odds of hitting a set are close to 8-1, and you're not going to get stacks in every time you hit, so you need to be conservative when playing anything worse than 88 imo.
That said, there's nothing wrong with just throwing it away if you're on a nitty table; you can get into bad spots if you're not careful vs 3Bets, or not all that confident postflop.