No. Open tight from the SB, unless you have reads BB is a nit. Trust me. I have played 5NL all the way to 100NL on Zone, and you really want to tighten up in the SB. You will be OOP for the whole hand, and the BB will make moves on you postflop.
It's not just about him needing to fold 54% of the time to make it profitable. You will most likely make more mistakes postflop OOP, and you cannot control the size of the pot as easily OOP. And when you do have the best hand, it's going to be easy for the BB (who has position on you) to bluff you off your hand. You will also have reverse implied odds
when you pair your A no kicker, K no kicker, etc.
If you have any other questions about Zone, I can answer them . I'm a regular on 100NL Zone, and have played a ton of hands on there as well as on the lower stakes.