I always try to pick a table with no more than 3 short stackers, and ideally they would be sitting to my immediate left, all 3 in a row so they have position on me, but I have position on the deeper stacks.
Short stackers don't have the implied odds to play speculative hands against. They should be playing only premiums, as that is all there stack should allow, and you should only be playing premiums against them because if you are HU in a pot with a shortstack essentially you stack is only as big as theirs...since you can only win as much as their stack. If you are in a 3way(or more) pot with a big stack and a shortstacker, than I see a lot of times the big stacks going at it, and almost ignoring the SSS, because of the money they can make over the 20bb or so that the sss put in.
Another thing is you have to watch the shortstackers to see which ones are playing a SSS strategy, and which ones are just fish buying in for short and playing almost ATC.
Just my 2 cents..ppl pretty much said the same thing above.