From what position? Position will matter a lot I would think with a hand like A10 off or even AJ off.If it folds to you in the cut off and you open raise, any Ace better than yours would 3bet most of the time. Yes, sometimes not but often enough. The button, late position, and blinds should be 3 betting you with better and if someone limps in early position and then 3 bets when it comes around you know you are in bad shape then too. Keeping mental notes of your opponents 3 betting tendencies will help and if they are playing stronger hands passively, you may lose a pot or 2 until you make the right adjustments.
If you limp A 10 or don't pay attention to position and who's doing what it can get you into trouble but playing in good position, opening for a reasonable amount, knowing your opponents 3 betting tendencies, and making the right folds to aggression that has a stronger range/position than you can save you a lot of money in the long run.
This is all very general though. Lot's more to consider but A 10 doesn't have to be a losing hand. Playing to your opponents ranges can help make decisions a little more clear.