Agreed. It's generally a bad idea to be playing hands that have only one way of hitting big. The only exception is AAxx in some spots where you can isolate and play the AA for pair value and not just set farm it (much more doable at 6-max than FR). Low to medium pairs have to have some heavy draws or another pair with them to make them worthwhile. I recall seeing the Poker Tracker Omaha stats of a good player, and those uncoordinated low pairs were played for a loss.
Post-flop, I don't think your play was that bad, but I have one comment. You don't always have to bet pot. In this hand, I really don't think you need to bet the turn that strongly. That turn is mostly a blank. While a pot sized bet would most likely be a good idea versus AK, the odds
of him having AK are rather low. Unless he's a big donk, he'd only call a flop pot bet in a 5-way pot with AK hands like AK9x, AK7x, AKT8, AK86, or something like that. Plain top pair top kicker is very weak. I think it's a lot more likely that he has a set, flopped two pair, or a big draw. The weaker two pairs often fold to two pot sized bets, so I think a pot sized bet is pushing out all the hands you're in good shape against. I'd go for something slightly smaller. Also, I don't know how much you had left relative to the pot on the river, but I don't like a big bet on the river. Bottom set doesn't get paid off by much on the river, even if no straights or flushes are possible. And since you've been showing aggression on every street, you've pretty much defined your hand as being very strong. I think a big bet will get all of the hands you beat to fold. I'd make a small value bet or depending on the tightness of the villain, no bet at all.
Edit: I don't mind playing bare AA, KK, or QQ in games with a very large number of players limping to see the flop. You're going to hit set over set pretty often, so the implied odds are good.