Depends on the individual ,but in position feel free to flat more and let them hang themselves. Be aware of board texture though and draws they may be chasing as their range will be much wider. Just always play in position against them, OOP you're gonna have to be prepared to face 2-3 barrels which isn't easy with marginal holdings.
OOP with hands like 88 as you mentioned, just flat if they have low F3bet% and set mine when you have the odds
. When they are making it 4bb from CO they probably have a monster so set mining is good here.