short-stacked (cca 3-6x the blinds/antes), i'd go all-in regardless of anything.
mid-stacked (cca 10x blinds/antes), i'd raise 3-5xBB, hoping to attract 1-2 opponents into the pot, varying the raise amt for previously observed table behavior.
large-stacked, i'd still raise 3-5xBB, as above.
bottom line, with big pocket pairs, i'd ideally want no more than 2 opponents going into the pot with me, as statistically i'm worse off the more ppl are in.
(insert your favorite bad beat stories here. lol)