My 2 cents.
1. Make mega 3 bets with AA against super fish because we are not folding AA against such players so always make it unprofitable for them to call you.
2. Sometimes go for an extraordinary raise when playing mega fish on wet boards with a really strong hand like top 2 pair or set.
3. If there is no fish on the table just leave. Doing that doesnt mean you accept "defeat" to regs or that we are afraid of them. We are simply here to make money and we are not getting into any matters of pride and rivalry.
4. Again concerning mega fish don't hesitant to shove 100 BB pre with AK they will call you with AQ/AJ or even worse at times.
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I'd say for microstakes:
Don't focus 100% on your cards, play the player as well.
If you're playing against a passive calling station that will check/call bottom pair... DON'T BLUFF for FFS! If a passive player raises you for an absurd amount just fold the hand. If they're loose passive or rock tight I'm folding over 75% of the time if my hand isn't looking good.
If you're playing a nit tight player that will only call with the NUTS, fold with the QUICKNESS if they shove. If you're using a HUD you can just see by their (AF - Aggression Factor) & see how tight their Voluntary Put in pot (VPP) Also if nitty players fold a lot... (Steal their blinds, C-bet them off the flop, and etc.)
Loose passive & calling stations -> Value bet them to death.
Loose aggressive -> pray that they give up all of their chips/money when you hit a monster hand on the flop.
Bluff the scared money & extract as much money from the calling stations. Also I like to mix up my hand range. If I raise only my premium hands, my range becomes very predictable & easy to exploit. So I switch up what I'm raising to keep the other players guessing as to what I'm holding.