On the one hand, if the big stack is to your right, you can be protected from a lot of marginal hands. The big stack makes many of your iffy decisions for you, when he is aggressive, you want to be extremely strong to even get into the pot.
On the other hand, if the big stack is too your left, you will have to be almost ultra aggressive to get him to respect you. This puts you in serious jeopardy.
You can't steal as often, and bluffing becomes less profitable.