Basically, you just have to play hands that'll be able to scoop.
A234 and A235 double suited are as good as it gets.
If you're gonna play for the high hand, then AAKK, TJQK, AAJT, double pairs, those are decent.
Avoid middle cards like 6789 which look good but are really only playing for 1/2 a pot. It'll end up costing you.
Low hands that can develop into a high as well are where it's at. If you play a strategy that throws away every hand that doesn't have an ace in it, you won't be doing much wrong. Aces are the key in O8.
I know this is a wicked rough overview, I'll look for a more in depth link for you. Supersystem 2 I believe contains a section on O8.
Here's a link