The way I interpreted the original poster's question, the action before you indicates that there are little to no A or K left in the deck. So your hand will more or less be A high. That's fine against the other A-rag and K-rag hands, but you will likely lose to any pocket pair.
Let's say someone has a pocket pair, sees the same action that the original poster saw, and concludes that none of the A-rag and K-rag hands are going to improve their hands above his pocket pair. So he's going to stick around. Does someone's range of pocket pairs have to be taken into account on this as well?
It still seems like the preflop raise is a good more here, but if there's a calling station with pocket pairs, it's going to be a painful hand for AK.
I guess first off, I am speaking in MTT and STT situations, and dont know if OP is referring to cash, in which cast this is TL;DR
For me, the action before does not indicate little or no AK left at all. The initial raiser could have a wide range of hands here, and reads will be important - as they will on all callers to follow, if available. Lets go from random players.
Initial raiser: AA-TT maybe 99 in MP. AQ+, AJs+ (and MTT depending on relative stacks perhaps 9Ts+ or even 44+ or given some players a lot more.....)
What is the first caller's range going to be? Certainly high A's, but a lot more hands as well. Also read dependent, for example the 1st caller is observant and thinks the following players are stations, he will call with a very wide range here KQ, KTs, most PPs, many high connectors SC and high suited gaped connectors, where as if the following players are LAG, he may be folding all but his better hands here, and he will be re raising if he stays in. He will be raising any AK or AQs if he plays them, so a call is telling me his range is not Ax here as much as PP,SC or BW s and os.
Second caller - his
pot odds let him call with a very wide range here, now Axs - A3-5 - are in his range, but also a wide variety of other cards here.
So my point is, I am not counting my As and Ks as lost outs here, and am 3 betting if I am staying in this pot, which I am going to do most of the time, and will need a good reason to NOT 3 bet here. (I am not saying there will never be situations where I am mucking here, just that there wont be many, and they will need solid reasons)
I believe any action on the MP raise will be 3 bets with a high A, then I can decide when that happens how I see the 3 bettor and what I want to do now. If I 3 bet and get 4 bet on PF, then my reads will be important if I have any. Against a 9/7 my AK dont look so good no more. Against 54/38 I am sorely tempted to get it all in.