No, definitely not.
Assuming you are at micros, the same sort of play style still applies "TAG" - but you do have to take more marginal spots in 6max because of how quick the blinds reach you, so you can't just nit it up like in FR waiting for everyone to bust. You have to apply more pressure, shoving a bigger range of hands and picking great spots to do it in and assigning ranges of villians shoving range. You will find, during bubble time, you can literally own the bubble because of people wanting to try cash and the blinds/antes are worth a lot in these. Once you have this mastered, it should be a walk in the park!